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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may bring about an increase in methadone plasma concentrations, which could bring about probably fatal respiratory depression. In addition, discontinuation of concomitantly utilised cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers might also lead to an in